目的 研究巧克力囊肿腹腔镜手术患者采取GnRH及反加疗法治疗的价值及对血清激素水平、妊娠的影响.方法 方便选择该院2014年3月-2017年7月纳入的70例巧克力囊肿患者, 按照随机数字法分为研究组与对照组各35例,研究组在腹腔镜手术后采取GnRH及反加疗法,对照组在腹腔镜手术后采取GnRH治疗,对比两组血清激素水平及妊娠结局.结果 治疗前两组的雌二醇、卵泡刺激素及黄体生成素水平差异无统计学意义(t=0.997,0.061,0.185, P＞0.05),治疗后研究组雌二醇(24.39±6.22)pmol/L、卵泡刺激素(8.59±2.84)U/L水平低于对照组(74.54±10.37)pmol/L,(10.34±3.25) U/L(t=24.535,2.399,P＜0.05),但两组黄体生成素差异无统计学意义(t=0.239,P＞0.05);研究组不良反应发生率8.57％、复发率5.71％, 低于对照组20.00％、17.14％(χ2=5.335,6.455,P＜0.05), 但妊娠率51.43％高于对照组34.29％(χ2=5.998,P＜0.05); 治疗前两组的痛经、盆腔痛及性交痛评分差异无统计学意义(t=0.059,0.242,0.147,P＞0.05),治疗后研究组的各疼痛评分[(1.22±0.38)分,(1.14±0.36)分,(0.87±0.27)分]低于对照组[(1.50±0.47)分、(1.82±0.59)分、(1.42±0.45)分](t=2.741,5.821,6.200,P＜0.05).结论 巧克力囊肿患者采取腹腔镜手术与GnRH及反加疗法效果明显,可有效改善其血清激素水平,减少不良反应发生率,避免复发,提高妊娠率,降低疼痛,安全性高.%Objective To study the value of GnRH and anti-addition therapy in patients with chocolate cyst laparoscopic surgery and its effect on serum hormone levels and pregnancy. Methods 70 patients with chocolate cysts were convenient selected and enrolled in our hospital from March 2014 to July 2017. According to the random number method, 35 patients in the study group and the control group were enrolled. The study group took GnRH and anti-addition therapy after laparoscopic surgery. The control group received GnRH after laparoscopic surgery, and the serum hormone levels and pregnancy outcomes were compared between the two groups. Results There were no statistically significant differences in estradiol, follicle stimulating hormone and luteinizing hormone levels between the two groups before treatment (t=0.997, 0.061, 0.185, P＞0.05). After treatment, estradiol (24.39±6.22)pmol/L, follicle stimulating hormone (8.59±2.84) U/L lower than that of the control group (74.54±10.37)pmol/L,(10.34±3.25)U/L (t=24.535, 2.399, P＜0.05), but the two groups of luteinizing hormone had no statistically significant difference (t=0.239, P＞0.05); the incidence of adverse reactions in the study group was 8.57％, and the recurrence rate was 5.71％, which was lower than that of the control group 20.00％, 17.14％ (χ2=5.335, 6.455, P＜0.05), but pregnancy rate of 51.43％ was higher than that of the control group 34.29％ (χ2=5.998, P＜0.05). There was no statistically significant difference in the dysmenorrhea, pelvic pain and sexual pain scores between the two groups before treatment (t=0.059, 0.242, 0.147, P＞0.05). The pain scores of the study group after treatment[(1.22±0.38)points,(1.14±0.36)points,(0.87±0.27)points] were lower than those of the control group [(1.50±0.47)points,(1.82±0.59)points,(1.42±0.45) points] (t=2.741, 5.821, 6.200, P＜0.05). Conclusion The patients with chocolate cysts have obvious effects in laparoscopic surgery and GnRH and anti-addition therapy, which can effectively improve serum hormone levels, reduce the incidence of adverse reactions, avoid recurrence, improve pregnancy rate, reduce pain and high safety.
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