小剂量环孢素联合左旋咪唑治疗非重型再生障碍性贫血的临床探讨

摘要

Objective To investigate the clinical observation of small dose of cyclosporine combined with levamisole in the treat-ment of non-severe aplastic anemia so as to provide a reference for clinical diagnosis and treatment. Methods This group of 82 cases with non-severe aplastic anemia were randomly divided into the control group and the treatment group with 41 cases in each. The control group was given small dose cyclosporine therapy, the treatment group was given small dose cyclosporine and lev-amisole treatment. 6 months was a course of treatment for both groups. Results Comparing the total effective rate of the treatment group (73.17%) with that of the control group (78.05%), the difference between the two groups was not statistically significant (P>0.05); comparing the hemoglobin, platelet, and neutrophil levels of the two groups after treatment with those before treatment, the differences were statistically significant (P<0.05). After treatment, the difference in hemoglobin and neutrophil levels between the treatment group and the control group was not statistically significant (P>0.05);the level of platelet of the treatment group was ob-viously higher than that of the control group, the difference was statistically significant (P<0.05). The total incidence of adverse re-actions of the treatment group (51.52%) was obviously lower than that of the control group (7.32%), the difference was statistically significant (P<0.05). Conclusion The effect of small dose of cyclosporine combined with levamisole on non-severe aplastic anemia is accurate, which can significantly reduce the incidence of adverse reactions of cyclosporine, and the treatment is worthy of clini-cal promotion.%目的：探讨小剂量环孢素联合左旋咪唑治疗非重型再生障碍性贫血的临床疗效，为临床诊断治疗提供参考。方法将该组82例非重型再生障碍性贫血患者按照随机数字表法将其分为对照组和治疗组，每组41例；对照组给予一定剂量环孢素治疗，治疗组给予小剂量环孢素及左旋咪唑治疗；两组治疗均以6个月为1个疗程。结果治疗组总有效率(73.17%)与对照组(78.05%)对比，差异无统计学意义(P>0.05)；两组患者治疗后血红蛋白、血小板、中性粒细胞水平与治疗前对比差异有统计学意义(P<0.05)；治疗组治疗后血红蛋白、中性粒细胞水平与对照组治疗后对比，差异无统计学意义(P>0.05)；治疗组治疗后血小板水平显著高于对照组治疗后，且差异有统计学意义(P<0.05)；治疗组总不良反应率(51.52%)显著低于对照组(7.32%)，且差异有统计学意义(P<0.05)。结论小剂量环孢素联合左旋咪唑治疗费重型再生障碍性贫血疗效确切，可显著减少环孢素的不良反应发生，该治疗方案值得临床推广。