两种不同RAS抑制剂与胺碘酮联合应用在高血压合并阵发性房颤中的疗效对比

摘要

Objective To investigate effect of candesartan cilexetil, enalapril combined with amiodarone therapy hypertensive pa-tients with paroxysmal atrial fibrillation. Methods 83 patients were randomly divided into two groups. Group A was given can-desartan cilexetilamiodarone, while Group B was given enalapril and amiodarone. Results SBP,DBP and atrial fibrillation of 6 months and 12 months in two groups was lower than pre-treatment(P<0.05). Comparing pre-treatment,atrial fibrillation of 6 months and 12 months in two groups had no difference (P>0.05). SBP,DBP,atrial fibrillation and left atrium of pre-treatment,6 months and 12 months in two groups had no significant difference (P>0.05). Conclusion Candesartan cilexetil, enalapril combined with amio-darone has a good effect.%目的：探讨坎地沙坦酯、依那普利与胺碘酮联合应用在高血压合并阵发性房颤中的效果。方法整群选取2012年5月—2014年2月该院收治的83例高血压合并阵发性房颤病人,按照随机数字表法分为A组(n=41)和B组(n=42)。A组给予坎地沙坦酯、胺碘酮联合治疗,B组给予依那普利、胺碘酮联合治疗,对比两组治疗效果。结果A组、B组治疗后6个月、12个月的SBP水平、DBP水平、房颤发作次数均显著地低于治疗前(P<0.05)；A组、B组治疗后6个月、治疗后12个月左心房内径与治疗前相比,差异无统计学意义(P>0.05)；A组、B组组间治疗前、治疗后6个月、治疗后12个月的SBP水平、DBP水平、左心房内径大小、房颤发作次数相比,差异无统计学意义(P>0.05)。结论坎地沙坦酯或者依那普利联合胺碘酮均可有效地治疗高血压合并阵发性房颤,效果确切。