Objective To observe and study the clinical effects of dexmedetomidine given as painless gastrointestinal en-doscopy and treatment of narcotic drugs. Methods Random selection from May 2014 to November 2015 because of the stomach and the duodenum is unwell, need to accept the examination of 200 cases of patients with painless stomach and random grouping, the observation group (right beauty holds the mi anesthesia) and control group (fentanyl anesthesia) 100 cases each, compare the treatment effect of the two groups. Results The chances in patients with agitation, nausea and other adverse reactions was 7.00%, significantly lower than the control group(χ2= 6.95, P<0.05); and the observation group com-fort score was (8.57 ± 1.03) points higher in the control group and the observation group can wake up time (5.38 ± 1.20) min, compared with the control group decreased significantly, the difference was statistically significant(t = 13.27,16.48;P<0.05);two of propofol Compare the amount of phenol was no significant difference (t = 0.66,P> 0.05). Conclusion Painless gastroscopy examination and treatment, the application of dexmedetomidine were given safe anesthesia, the patient discom-fort weak and low incidence of adverse reactions, a higher application significance.%目的：观察并研究将右美托咪定作为无痛胃肠镜检查与治疗中麻醉药物的临床应用效果。方法随机选择该院2014年5月-2015年11月由于胃及十二指肠不适,需接受无痛胃肠镜检查的患者200例进行随机分组,即观察组(右美托咪定麻醉)与对照组(芬太尼麻醉)各100例,对比两组的治疗效果。结果观察组中出现躁动、恶心等不良反应的患者几率为7.00%,显著低于对照组(χ2=6.95,P<0.05)；且观察组的舒适度评分为(8.57±1.03)分高于对照组,而观察组的可唤醒时间为(5.38±1.20)min,与对照组相比有显著下降,差异有统计学意义(t=13.27,16.48；P<0.05)；两组的丙泊酚用量对比差异无统计学意义(t=0.66,P>0.05)。结论在无痛胃肠镜检查与治疗中,应用右美托咪定进行麻醉的安全性高,患者不适感弱,且不良反应发生率低,具备较高的推广应用意义。
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