Objective To studythe clinical effect observation of carboprost tromethamine injection combined with oxytocin in preventing postpartumhemorrhage. Methods To randomly select 96 patients with postpartumhemorrhage admitted in January 2015 to February 2016,and devide into control group and study group by random number method. The study group which includes 48 patients is given carboprost tromethamine injection combined with oxytocin; the control group which includes 48 patients is only given oxytocin; bleeding rate and adverse reactions were observed in the two groups. Results ①The amount of 24h bleeding in the observation group was significantly lower than that of the control group, and the number of bleeding cases were less than the control group, the bleeding rate was 2.1%, which was significantly lower than that of the control group 16.7%, P< 0.05. ②The incidence of adverse reactions in the control group and the observation group were 16.7%and 10.4% respectively, while the control group was slightly higher than the observation group, but no significant difference was observed, P>0.05. Conclusion The clinical effect observation of carboprost tromethamine injection combined with oxy-tocin in preventing postpartumhemorrhage is apparent, with less bleeding and lower bleeding rates and adverse effects, it is safe and reliable.%目的：研究卡前列素氨丁三醇注射液联合缩宫素预防产后出血的临床疗效。方法随机选取该院96例2015年1月一2016年2月收治的高危产妇,采用随机数字法分为对照组和观察组。观察组48例,娩出后给予卡前列素氨丁三醇注射液皮下注射联合缩宫素静脉滴注；对照组48例,仅注射缩宫素。观察两组患者产后出血量、出血率及不良反应。结果①观察组24 h内出血量明显低于对照组,出血例数少于对照组,出血率为2.1%,显著低于对照组16.7%,P＜0.05；②对照组和观察组均有数例患者发生血压升高、恶心、呕吐、心悸等不良反应,不良反应发生率分别为16.7%、10.4%,对照组略高于观察组,但差异无统计学意义,P＞0.05。结论卡前列素氨丁三醇注射液联合缩宫素预防产后出血效果较好,出血量、出血率均有显著改降低,不良反应未见增加,安全可靠。
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