Objective To discuss the effect of eelectrochemiluminescence immunoassay in the diagnosis and treatment of tumors of urinary system. Methods 42 cases of tumor patients, 35 cases of patients with acute urinary tract and 32 cases of healthy examined persons treated in our hospital from April 2014 to August 2015 were randomly selected as the observation object and respectively marked as the group A, group B and group C, and the measure results of urine CK19 of each group were recorded and given correlative analysis and comparison. Results The mean value of urine CK19 in the 32 cases of pa-tients without diseases of urinary system was (1.59±1.00) ug/L, there was no obvious statistical difference in the mean value of urine CK19 between the male and the female, P>0.05, and there was no statistical difference in the mean value of urine CK19 between different age groups, P>0.05, and the analysis concluded that the age and gender had no effect on the mea-sure value of urine CK19, and the positive rate of malignant tumors of urinary system was obviously higher than that in the group B (the benign disease of urinary system), (P<0.05), the positive rate of malignant tumors of urinary system was higher than the other cancer groups, P<0.05, meanwhile, the measure value of CK19 in the malignant tumors of urinary system group was obviously higher than that in the group B (acute urinary tract group), P<0.05. Conclusion The dynamic observa-tion of changes of content of urine CK19 fragment can reduce the false positive rate of acute urinary tract infection and de-tection and improve the significance of urine CK19 in diagnosis of urinary system, which is worth clinical promotion and ap-plication.%目的：探究电化学发光免疫分析技术在泌尿系统肿瘤诊治中的作用。方法随机选取2014年4月—2015年8月该院泌尿科收治的42例肿瘤患者、35例急性尿路患者、32例健康受检者作为观察对象，分别记为A组、B组、C组。收集各组尿样，记录各组尿CK19测定结果，进行相关分析与对比。结果32例无泌尿系统疾病者尿CK19平均值为(1.59±1.00）ug/L，男性与女性尿CK19平均值对比差异无统计学意义(P>0.05）；且年龄组间尿CK19平均值对比差异无统计学意义(P>0.05），分析得出，年龄及性别不影响尿CK19的测定值。泌尿系统恶性肿瘤阳性率明显较B组(泌尿系统良性疾病组）高(P<0.05）；与其他癌症组阳性率对比，泌尿系统恶性肿瘤阳性率同样比其高(P<0.05）。与此同时，泌尿系统恶性肿瘤组及其他癌症组CK19测定值均明显高于B组(急性尿路组）(P<0.05）。结论动态观察尿CKl9片段的含量变化，能降低急性尿路感染检测假阳性率，增加尿CKl9片段诊断泌尿系统肿瘤的意义，值得临床推广、应用。
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