Objective To study the clinical characteristics of neonatal bacterial meningitis. Methods Selected 90 cases with neonatal bacterial meningitis February 2014 to March 2015 in admitted to our hospital, according to the age of children into early onset neonatal group(≤7 days), late neonatal group(≤7days)in two groups of 45 patients were analyzed retrospectively for children with clinical data. Results The two groups of children in the group of early neonatal neurologic symptoms more atypical;incidence of complications between the two groups of children, P>0.05, had no difference statistically signiifcance. Increased white blood cell count(56 cases, 62.2%), cerebrospinal fluid white blood cell count was significantly higher (87 cases, 96.7%), CSF glucose concentration decreased(15 cases, 16.7%), cerebrospinal lfuid protein increased(42 cases, 46.7%), blood culture The positive rate was 27.8%(25 cases), cerebrospinal fluid culture positive rate was 16.7% (15 cases), early neonatal bacterial culture positive group was signiifcantly lower than late neonatal group, P<0.05, had difference statistically signiifcance. Hearing damage occurs in two groups of children were 6 cases of children belonging to late neonatal group. Conclusion The clinical features of neonatal bacterial meningitis is more a lack of early neonatal characteristics more obvious, the lower rate of positive cultures of bacteria, meningitis in children need early treatment, complications may arise in children respond to intervene.%目的：研究新生儿细菌性脑膜炎的临床特征。方法选取2014年2月～2015年3月我院收治的新生儿细菌性脑膜炎患儿90例对患儿临床资料、治疗方法进行回顾性分析，根据患儿发病日龄分为早期新生儿组（≤7 d）、晚期新生儿组（＞7 d）两组，每组45例。结果两组患儿中的早期新生儿组的神经系统症状更加不典型；两组患儿的合并症发生率对比，P＞0.05，差异不具有统计学意义。其中白细胞计数上升（56例，62.2%）；脑脊液白细胞计数升高（87例，96.7%），脑脊液糖浓度下降（15例，16.7%），脑脊液蛋白上升（42例，46.7%）；血培养阳性率为27.8%（25例），脑脊液培养阳性率为16.7%（15例），早期新生儿组细菌培养阳性率低于晚期新生儿组，P＜0.05，差异具有统计学意义。两组患儿中出现听力损害的6例患儿均属于晚期新生儿组。结论新生儿细菌性脑膜炎的临床特征较为缺乏，早期新生儿特征更不明显，细菌阳性培养率较低，出现脑膜炎的患儿需尽早治疗，对患儿可能出现的并发症加以干预。
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