PS应用于新生儿奶汁吸入性肺炎治疗的临床疗效观察

摘要

Objective To explore the application of PS in neonatal milk aspiration pneumonia.Methods10 cases of neonatal milk aspiration pneumonia with PS endotracheal injection therapy as study group, while 8 cases of neonatal milk aspiration pneumonia with refusing to use PS treatment in the same period as control group. Control group received routine treatment, such as preventing infection and nutrition support, on the basis of routine treatment, study group was treated with PS endotracheal injection therapy admitted to hospital within 2h. The changes of pH, PaCO2 and PaO2 in two groups was monitored regularly, to count and compare oxygen therapy time, noninvasive respiratory support cases and hospitalization days between two groups.Results After the application of PS 6 h 24 h, PaO2, PaCO2 and pH in study group were significantly improved than before treatment, differences in corresponding time point had statistical signiifcance between two groups (P<0.05). Oxygen therapy time, numberof NCPAP treatment and hospitalization days in study group were better than control group (P<0.05). There had no significant differences in the pulmonary infection, gas leakage, bronchial dysplasia and death between two groups (P>0.05).Conclusion The application of PS in the treatment of neonatal milk aspiration pneumonia can be gained curative effect.%目的：探讨PS在新生儿奶汁吸入性肺炎中的应用。方法以使用PS气管内注入治疗的10例新生儿奶汁吸入性肺炎为研究组，以同期拒绝使用PS治疗的8例新生儿奶汁吸入性肺炎病例为对照组，对照组仅给予预防感染、营养支持等常规治疗，研究组在常规治疗的基础上于入院2 h内给予PS气管内注入治疗，定时监测两组PaO2、PaCO2和pH值变化，统计并比较两组氧疗时间、无创呼吸支持例数和住院天数。结果研究组应用PS后6 h、24 h监测PaO2、PaCO2和pH值较用药前显著改善，两组对应时间点差异有统计学意义（P＜0.05）。研究组氧疗时间、NCPAP治疗例数及住院天数均优于对照组（P＜0.05）。两组患儿合并肺部感染、气漏、支气管肺发育不良及死亡情况比较差异无统计学意义（P＞0.05）。结论 PS应用于新生儿奶汁吸入性肺炎治疗可取得显著疗效。