血清肿瘤标志物联合检测在结直肠癌患者病情监测中的应用研究

摘要

Objective The effect of application of combined detection of serum tumor markers in patients with colorectal cancer was studied and analyzed.Methods 128 cases of colorectal cancer in our hospital from July 2013 to July 2014 were selected. All patients were divided into 2 groups according to different tumor stages, 56 cases in groupⅠ-Ⅱ and 72 in groupⅢ-Ⅳ. The level of serum tumor markers in the two groups was compared with the serum tumor markers in 1 years, 2 years after chemotherapy.Results The level of CEA, CA19-9 and CA242 in group I - II group was lower than that in group III - IV group and the difference was statistically signiifcant (P<0.05). After 1 years of chemotherapy, there was no significant difference between the recurrence and metastasis of CEA, CA19-9, CA242, CA724, and the difference was statistically significant (P<0.05). After 2 years of chemotherapy, there was a signiifcant difference in CA19-9, CA242, AFP, CA724, and CEA (P<0.05) among those without recurrence and metastasis.ConclusionDetection of serum tumor markers in patients with colorectal cancer has signiifcant effect, which can effectively evaluate whether relapse after chemotherapy in patients with metastasis.%目的：研究分析血清肿瘤标志物联合检测应用于结直肠癌患者病情监测中的应用效果。方法选取2013年7月～2014年7月我院收治的结直肠癌患者128例，将所有患者按照不同肿瘤分期分为Ⅰ-Ⅱ期组56例、Ⅲ-Ⅳ期组72例，对比两组血清肿瘤标志物水平和化疗后1年、2年复发转移者与未复发转移者的血清肿瘤标志物水平。结果Ⅰ-Ⅱ期组CEA、CA19-9、CA242水平低于Ⅲ-Ⅳ期组，差异有统计学意义（P＜0.05）；化疗1年后，未复发转移者CEA、CA19-9、CA242、CA724低于复发转移者，差异有统计学意义（P＜0.05）；化疗2年后，未复发转移者CEA、CA19-9、CA242、AFP、CA724均低于复发转移者，差异有统计学意义（P＜0.05）。结论血清肿瘤标志物联合检测应用于结直肠癌患者病情监测效果显著，可有效评估患者化疗后是否出现复发转移。