精子DNA损伤对试管婴儿助孕结局的影响探讨

摘要

目的：探讨精子DNA损伤对试管婴儿助孕结局的影响。方法选择我院160例实施试管婴儿的精子作为检测对象，依据精子DNA损伤情况分损伤组和正常组，对助孕结局的影响进行探讨。结果损伤组经统计示精子顶体酶活性、精子浓度、正常形态精子百分率、精子活力、优质胚胎率及试管婴儿受精率等均低于正常组，差异有统计学意义（P＜0.05），胞质内单精注射（ICSI）受精率高于正常组，差异有统计学意义（P＜0.05），损伤组经统计活产率为30％，正常组活产率为50％，两组间活产率比较差异有统计学意义（P＜0.05）。结论精子DNA损伤检测在试管婴儿的风险预测中，可作为有效参考指标。%Objective To explore the effect of sperm DNA damage on IVF pregnant outcome.Methods160 copies of the implementation of IVF sperm as detection object in the hospital were divided into the injury group and the normal group according to the test results on the sperm DNA damage, the effect of IVF outcome was discussed.Results The injury group by stasistic showed the sperm acrosin activity, sperm concentration, percentage of normal sperm morphology, sperm motility, good quality embryo rate, fertilization rate of IVF were lower than that in the normal group, the difference was statistically significantly (P<0.05), fertilization rate of ICSI was more than that in the normal group, the difference was statistically significantly (P<0.05),the results of the injury group after statistical showed the live birth rate was 30%,and the normal group was 50%,there was statistically significantly between two groups (P<0.05). Conclusion Risk prediction of sperm DNA damage detection in a test tube baby can be regarded as the effective reference index.