经典与非经典抗精神病药物对精神分裂症患儿血清Hcy水平及认知功能的影响

摘要

目的：探讨经典与非经典抗精神病药物对精神分裂症患儿血清同型胱氨酸（Hcy）水平及认知功能的影响。方法选择2014年1月～2015年2月来我院精神科就诊的精神分裂症患儿60例最为本项研究对象，平均分为两组研究组和病例对照组，研究组患者给予非经典抗精神病药物，病例对照组患者给予经典抗精神病药物治疗。另选30例健康儿童进行对照。测定三组患者治疗前后Hcy水平和事件相关点位（ERP）。结果研究组患儿和病例对照组患儿治疗前血清Hcy水平较健康组水平偏高，ERP测定中N2波潜伏期（PL）、P3PL延长。采用各自的药物治疗后，研究组患儿Hcy水平降低，PL、P3PL缩短。病例对照组患儿的Hcy水平、PL、P3PL变化不明显。治疗后两组患儿的上述指标存在差异性。结论精神分裂症患儿Hcy水平偏高，认知功能损害，给予非经典抗精神药物后Hcy水平和认知功能改善。%Objective To investigate the effect of classical and non classical antipsychotic drugs on serum homocysteine (Hcy) level and cognitive function in patients with schizophrenia.Methods From January 2014 to February 2015, 60 patients with schizophrenia in our hospital from February to, the study group were divided into two groups. The study group were treated with non classical antipsychotic drugs. Another 30 cases of healthy children were. Hcy level and event related points (ERP) were measured before and after treatment in three groups.Results In the study group, the serum Hcy level was higher than that in the control group, and the N2 wave latency (PL) and P3PL was prolonged in ERP test. After treatment, the levels of Hcy in the study group were decreased, P3PL and PL were shortened. Hcy level, P3PL and PL were not signiifcantly changed in the control group. After treatment, the two groups of children with the above indicators are different.Conclusion The levels of Hcy in patients with schizophrenia were high, and the level of cognitive impairment,and the improvement of Hcy and cognitive function after non classical antipsychotic drugs were given.