基于DNA分子的纳米功能材料的设计、组装及应用

摘要

DNA除了作为一种遗传信息的载体分子之外,还可以通过折叠或组装从而形成特定的二维和三维结构.通过设计DNA分子的结构并探索其与纳米材料之间的相互作用的研究已经引起了国内外学术界的持续关注.DNA功能化的无机纳米材料促进了分析科学、生命科学以及环境科学的快速发展.本文将从疾病分子机制研究、疾病诊断和疾病治疗三个角度出发,探究面向生物医学分析应用的DNA分子功能化的无机纳米材料的设计与组装.除此之外,还对DNA功能化纳米材料技术的发展前景进行了展望.%In addition to being a carrier of genetic information,DNA also can be folded or assembled into specific two or three dimensional structures.The design of DNA nanostructures and explore its interaction with nanomaterials have been attracted considerable attention.DNA functionalized inorganic nanomaterials have promoted the rapid development of analytical science,life science and environmental science.Here,we will discuss the design and assembly of DNA functionalized inorganic nanomaterials for biomedical applications,from the perspective of molecular mechanisms,disease diagnosis and therapy.In addition,the future development of DNA functionalized inorganic nanomaterials in biomedical field will also be discussed.