核酸适配体修饰的纳米脂质体的制备及靶向毒性研究

摘要

Liposome nanocarrier target drug delivery system was constructed by self-assembly of DSPE-PEG5000-Aptamer and DSPE-PEG2000.And the aptamer was exposed on the surface of the carrier.Cellular up-take capacity of cancer cells was enhanced.Target toxicity against breast cancer cell MCF-7 was investigated. Results showed that liposome nanocarrier target drug delivery system could enhance the cancer cells specific in-ternalization and improved anti-cancer efficacy.%将核酸适配体修饰的 DSPE-PEG5000（DSPE-PEG5000-Aptamer）和 DSPE-PEG2000自组装构建纳米脂质体靶向载药体系，使核酸适配体充分暴露在载体表面，提高了癌细胞对药物的摄取能力，并考察了载药体系对乳腺癌细胞 MCF-7的靶向毒性。结果表明，构建的纳米脂质体靶向载药体系能选择性进入癌细胞，增强药物的抗癌能力。