噁唑霉素及其类似物是由一些链霉菌产生的抗生素，它们都由3个基本骨架单元连接，其独特的生物活性和新颖的化学结构吸引了越来越多的化学与药物化学研究者的关注，从最初发现至今已经有很多研究小组报道了相关的合成研究成果。本文作者基于3个基本组成结构单元，综述了其合成的研究进展，分析了每种合成方法所采用的关键策略，并对该类药物的全合成前景进行了展望。%Oxazolomycin and its relevant analogs are isolated from a strain of Streptomyces ,all containing three fragments .Due to its structural originality and potent biological activities , these natural products have attracted considerable attention from the medicinal chemistry com‐munity .Since the first discovery ,several research groups have reported the synthesis of ox‐azolomycin or its analogs .Here in ,we detail the approaches taken by several research groups that are actively engaged in the synthesis of one or more of oxazolomycins based on the three fragments .The key synthetic strategies and methods of some reported routes are briefed .Mo‐reover ,suggestions are given on the development of the total synthesis of oxazolomycins .
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