米格列醇的合成

摘要

Miglitol were synthesized from 2,3,4,6-tetra-O-benzyl-glucopyranose as a starting material by four-step reactions inclu-ding reduction,swern oxidation,double reductive amination and catalyzed hydrogenolysis with an overall yield of 50%. This method used 2-aminoethanol to react with 1,5-dicarbonyl derivative of tetrabenzyl glucose directly in double reductive amination. The struc-tures of synthesized compounds were identified by 1 H-NMR and 13 C-NMR spectroscopy etc.%以2,3,4,6-O-四苄基-D-葡萄糖为原料,经还原,Swern氧化,双还原胺化,催化氢解脱苄基得米格列醇,四步反应总收率为50%。该过程首次用乙醇胺直接与四苄基葡萄糖二羰基衍生物进行双还原胺化反应合成了米格列醇,是一条合成米格列醇的新路线。所得化合物的结构通过1 H-NMR,13 C-NMR和MS进行确证。