琥珀氯霉素的合成工艺改进

摘要

The effects of molar ratio of succinic anhydride to chloramphenicol, reaction temperature and reaction time on the synthesis of chloramphenicol succinate from chloramphenicol and succinic anhydride using pyridine as catalyst and solvent were investigated. The results showed that the yield of chloramphenicol succinate reached 68.3% under the conditions of mass ratio of pyridine to chloramphenicol 10, succinic anhydride to chloramphenicol 1.2, reaction temperature 80 ℃ and reaction time 2 h.%以吡啶为催化剂兼溶剂,氯霉素与琥珀酸酐为原料,考察了琥珀酸酐与氯霉素物质的量之比、酯化温度、酯化时间对反应的影响.结果表明,吡啶质最为氯霉素的10倍,当琥珀酸酐和氯霉素的物质的量之比为1.2,酯化温度为80℃,反应2 h,琥珀氯霉素产率可达到68.3%,纯度达到98.5%.