第二代Grubbs催化剂配体的合成及优化

摘要

Grubbs催化剂是一种用于烯烃复分解反应的配位化合物,其中的配体对于催化剂的催化性能、稳定性有很大的影响. 目前,N-杂环卡宾( N-heterocyclic carbenes,NHC)是第二代Grubbs催化剂中的一个关键配体. 本文以乙二醛为原料,通过取代、还原、环化等反应,合成了一种氮杂环卡宾的前驱体1 ,3-二取代-2-羧基咪唑啉. 在此基础上,对部分关键合成环节进行了优化. 研究结果表明,在乙二醛-双-( 2 ,4 ,6三甲基苯基)亚胺的合成过程中,随着反应温度的升高,产率逐渐升高,后有所降低. 在3-( 2 ,4 ,6三甲基苯基) -2-羧基咪唑啉的合成过程中,反应时间对收率影响最大.%Grubbs catalyst is a coordination compound for olefin metathesis. The ligand in the Grubbs' catalyst has great influence on the function and stability of the catalyst. At present, N- heterocyclic carbene ( NHC) is a key ligand for the second generation of Grubbs' catalyst. In this paper, using glyoxal as raw materials, 1,3-substituted-2- carboxy-imidazoline as pre-heterocyclic carbene was synthesized by substitution, reduction and cyclization re-actions. On this base, some key steps were optimized by reaction temperature and time.