In this paper, the research progress in amphiphilic hyperbranched polymers is overviewed. Synthetic methods of amphiphilic hyperbranched polymers are introduced, which covers the modification of end groups of the hyperbranched polymers with long chain alkyl and polyethylene glycol, and the polymerization of vinyl derivatives through free radical polymerization or ring-opening polymerization, using hyperbranched polymers as macroinitiator. Different structures of amphiphilic hyperbranched polymers have their unique properties in solution, such as core-shell unimolecule micelles and different micellar conformation aggregates. Moreover, the application of amphiphilic hyperbranched polymers, such as drug delivery carrier, material modification, and the encapsulation of dye molecules is also introduced. Then, the development trend of amphiphilic hyperbranched polymers is proposed. The preparation of special properties of amphiphilic hyperbranched polymers and the application of amphiphilic hyperbranched polymers in biological medicine should be the main focus in the development of amphiphilic hyperbranched polymers.%介绍了两亲性超支化聚合物的合成方法,利用长链烷基和聚乙二醇对超支化聚合物端基接枝改性；或者对超支化聚合物改性引入活性位点,再利用其引发乙烯基单体,通过自由基聚合、开环聚合得到两亲性超支化聚合物.阐述了不同结构的两亲性超支化聚合物在溶液中的独特性质,如核壳型单分子胶束以及不同胶束形态的聚集体.详细介绍了两亲性超支化聚合物在药物输送载体、材料改性以及染料分子的封装等领域的应用现状,指出采用新的改性技术、聚合技术制备具有特殊性能的两亲性超支化聚合物以及探索其在生物医药领域的研究为今后的主要发展方向.
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