Cell immobilization technology was developed in 1970's based on the enzyme immobilization. Recently,cell immobilization is widely used in research and production of fuel ethanol. It demonstrated great potential with advantages of repeated applications,continuous operations,and high ethanol yield. So researches on cell immobilization in ethanol production are very important for practical applications. This article reviewed research progresses on cell immobilization in ethanol production. The article discussed the common methods,characteristics and advantages and applications of cell immobilization,problems,and solutions. The keys for future ethanol productions are developing co-immobilization of cell-cell,cell-enzyme and self-immobilization cell technologies, and developing new immobilization support materials for ethanol production.%固定化细胞技术出现在20世纪70年代后期,是在固定化酶基础上发展起来的.近年来,固定化细胞技术被广泛应用于燃料酒精的研究与生产中.因其可以反复使用、连续发酵以及提高酒精得率等优势显示了巨大的发展潜力.研究固定化细胞酒精发酵具有十分重要的现实意义.本文综述了固定化细胞技术在酒精发酵领域的研究进展,介绍了酒精生产中常用的细胞固定化方法、特性及优势、固定化细胞技术在酒精发酵中应用以及在酒精发酵中存在的问题及解决办法等.指出开展细胞与细胞、细胞与酶的共固定化技术,无载体自絮凝细胞固定化技术以及开发新型酒精专用固定化载体材料是未来固定化细胞技术在酒精工业规模化应用的关键.
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