大豆磷脂酰聚乙二醇单甲醚2000的制备及性能

摘要

With soybean phospholipid as raw material,first it was converted into sodium soy phospholipids and then reacted with monomethoxypolyethylene glycol 2000 tosylate (mPEG2000-OTs) to prepare soybean phosphatidyl methoxy polyethylene glycol 2000 ester(SP-mPEG2000). The experimental results were as follows: soybean phospholipid was reacted with 65mg NaH to obtain sodium soy phospholipids,m(sodium soy phospholipids)∶m(mPEG2000-OTs) = 0.45∶1,reaction time was 4 hours,reaction temperature was 90℃,and the conversion rate was 71.2%. The solid product is pale yellow color. Analyzed by1HNMR and IR,the product was proved to be SP-mPEG2000. This method has the characteristics of mild reaction condition and high utilization of soybean phospholipid. The critical micelle concentration of SP-mPEG2000 is 0.5g/L with surface tension of 42mN/m,The kinetic stability of SP-mPEG2000 was confirmed by emulsifying power ofn-hexane and water,which indicated that kinetic stability of the product is superior to soybean phospholipid powder.%以大豆磷脂为原料，首先制备出大豆磷脂酸钠，再与聚乙二醇单甲醚2000对甲苯磺酸酯（mPEG2000-OTs）反应制备大豆磷脂酰聚乙二醇单甲醚2000（SP-mPEG2000）。实验结果为：以65mg NaH处理大豆磷脂得到大豆磷脂酸钠，m(大豆磷脂酸钠)∶m(mPEG2000-OTs)=0.45∶1，反应时间为4h，反应温度为90℃，转化率为71.2%，产物为淡黄色固体。经1HNMR和 IR表征，证明为 SP-mPEG2000。该合成路线反应条件温和，大豆磷脂利用率高。SP-mPEG2000水溶液临界胶束浓度为0.5g/L，此时表面张力为42mN/m。通过 SP-mPEG2000对正己烷和水形成的乳状液的稳定性表征，表明产物的动力学稳定性优于大豆粉末磷脂。