组蛋白去甲基化酶JMJD3研究进展

摘要

Histone methylation state is dynamically regulated by different groups of histone methyltransferases and demethylases. H3K27me2/3 is controlled by the polycomb group proteins(such as methyltransferase EZH2),and its demethylation can activate gene expression. At present,two H3K27me3 demethylation enzymes,JMJD3 and UTX,have been identified. Moreover,a large number of studies have found that JMJD3 may promote cell differentiation and aging,and involve in the regulation of the occurrence and development of tumor. Here we summarize the roles and regulation mechanisms of JMJD3 in embryonic development as well as the occurrence and development of tumor,and the broad prospects in tumor diagnosis and treatment,for laying a theoretical basis for the future research work.%组蛋白甲基化状态是有不同类型的甲基转移酶和去甲基化酶来控制的.H3K27me2/3可以由多梳家族蛋白(如甲基转移酶EZH2)控制形成,其去甲基化后可以催化基因表达.目前共鉴定出JMJD3和UTX两种H3K27me3的去甲基化酶.大量研究发现,JMJD3可以促进细胞分化和衰老,参与调控肿瘤发生与发展.综述了JMJD3在胚胎发育及肿瘤发生、发展中的作用及其调节机制,并对其在肿瘤诊断和治疗方面的应用前景进行展望,旨为今后的研究工作奠定理论基础.