目的 比较颈动脉粥样硬化合并牙周炎的患者牙周基础治疗前、后血清炎症因子和血脂水平的变化,探讨牙周炎与动脉粥样硬化乃至冠心病间的关系,及牙周干预治疗对动脉粥样硬化患者病情发展的影响.方法 纳入体检中心彩超检查有颈动脉粥样硬化合并牙周炎患者32例,选取单纯牙周炎患者31例,实施牙周基础治疗.治疗前和治疗后3个月,分别对2组患者的血清c反应蛋白、总胆固醇、低密度脂蛋白水平进行检测、比较.结果 动脉粥样硬化伴牙周炎患者治疗前后血清炎症因子、脂质水平改变有显著差异(P<0.05),单纯牙周病组治疗前、后血清炎症因子水平改变有显著差异(P<0.05),血脂水平无明显改变.2组各自治疗前、后的牙周指标对照有明显改善.结论 慢性牙周炎基础治疗可改善牙龈、牙周局部炎症状态,降低血清炎症及动脉硬化患者血脂水平,有利于动脉粥样硬化的预防和改善.%Objective To observe the effect of no-surgical periodontal therapy on the level of inflammatory factors and lipids in serum of patients with periodontitis and atherosclerosis. Methods A total of 32 patients with periodontitis and atherosclerosis and 31 pationts with periodontitis were included in the study. The levels of serum inflammatory factors and lipids were detected by double antibody sandwich ELISA method before and after periodontal intervention. Results The levels of nflammatory factors and lipids in patients with periodontitis and atherosclerosis before therapy was lower than those after therapy (P<0. 05),and the level of nflammatory factors in pationts with periodontitis was lower after therapy. The level of lipids in pationts with periodontitis was not significantly different (P>0. 05). Conclusion Non-surgical periodontal therapy could decrease the level of serum inflammatory factors,which is beneficial to the prevention atherosclerosis.
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