细胞自噬与幽门螺杆菌感染

摘要

幽门螺杆菌是一种广泛定植于人胃黏膜的革兰阴性菌,它通过逃逸机体局部免疫杀灭而持续感染,最终导致胃上皮损伤,与多种胃部疾病相关.自噬是进化过程中保留的细胞机制,既能清除胞质内容物,又不影响细胞的生存.幽门螺杆菌能够入侵胃上皮细胞和某些免疫细胞,诱导自噬的发生,并在自噬体中自我复制后被清除,推测自噬可能在幽门螺杆菌感染中扮演重要的角色.%Helicobacter pylori is a gram-negative microbial pathogen that causes erosions of gastric epithelial cells,via escaping immune killing in local, which leads to a sustaining infection which is associated with various gastric diseases.Autohagy is an evolutionary cell mechanism which not only eliminates intercellular microorganisms, but also has no harm to tissue cells.Helicobacter pylori invade into gastric epithelial cells and certain immune cells, inducing autophagy, and are cleared off after replicating in the autophagsomes.It is assumed that autophagy might play an important role in Helicobacter pylori infection.