激活蛋白-2转录因子在乳腺癌中的作用

摘要

AP-2,a nuclear transcription factor family, is involved in the regulation of cell proliferation, differentiation, apoptosis and carcinogenesis. At least three of the five AP-2 family members have been identified, AP-2a, AP-2β and AP-2γ are related with the development of the breast cancer; transactivation fuction of AP-2 is regulated by tumor suppressor gene WWOX and P53,HER2 oncogene.traseriptional coactivators and AP-2 protein modifications.%激活蛋白-2 (AP-2)转录因子家族包括AP-2α、β、γ、δ和ε5个成员,在调节细胞增殖、分化和凋亡以及哺乳动物的胚胎发育中起到重要作用；近年研究发现激活蛋白-2与乳腺癌的发生相关,至少3个AP-2家族成员AP-2α、AP-2β和A P-2γ在乳腺癌中表达；抑制癌基因P53和WWvx、转录共激活物、癌基因HER2的表达、以及AP-2蛋白质的翻译后修饰都参与调控AP-2在乳腺癌中的作用.