猪血纤维连接蛋白促进小鼠Ⅲ度烧伤愈合

摘要

目的 研究相同浓度下不同纯度纤维连接蛋白对小鼠Ⅲ度烧伤创面愈合的效果及差异.方法 制备小鼠背部Ⅲ度烧伤模型,模型小鼠随机分5组:纤维连接蛋白高纯度组(85％)、中纯度组(75％)、低纯度组(65％)、贝复济阳性对照组以及空白对照组,观察各组创面愈合时间,脱痂时间及病理学变化.结果 不同纯度的纤维连接蛋白与空白对照组比较均能缩短小鼠皮肤创面愈合的时间及脱痂时间,并能显著改善创面皮肤的病理形态.结论 纤维连接蛋白对小鼠Ⅲ度烧伤愈合有显著促进作用,中纯度组可能具有潜在应用价值.%Objective To study the effects and differences of different purities of FN on wound healing of Ⅲ-degree burns in mice with the same concentration.Methods Establishing a model of skin Ⅲ-degree bums in mice,and dividing randomly into five groups:FN high purity group (85 ％),middle purity group (75 ％),low purity group (65％),Bei Fuji positive control group and blank control group.Observing the wound healing time,decrustation time and pathological changes in each group.Results All the different purity groups of FN shortened the wound healing time and decrustation time,and significantly improved pathological morphology of the bum skin,compared with the blank control group.Conclusions FN can significantly shorten the healing time of skin Ⅲ-degree burns in mice.The middle purity group may have the clinical value.