多溴联苯醚在啮齿类动物体内的代谢动力学研究进展

摘要

多溴联苯醚(PBDEs)是一类持久性有机污染物(POPs),其作为一种广泛使用的溴化阻燃剂在环境中普遍存在.PBDEs对生物体和人体存在内分泌干扰等毒性危害,正受到人们越来越多的关注.然而目前PBDEs对人体造成的影响都是由动物实验(主要是啮齿类动物)外推而得,因此研究不同的PBDEs同系物在啮齿类动物体内的代谢动力学参数是很重要的.重点综述PBDEs在啮齿类动物体内的吸收、分布、代谢和排泄,以期为开展这方面的研究,并进而评价PBDEs的环境危害和人体健康风险提供有价值信息.%Polybrominated diphenyl ethers (PBDEs) are considered as one kind of persistent organic pollutants (POPs),which are ubiquitous in the environment due to their widely used as flame retardants. More and more attention has focused on their hazardous effects on organisms and human. At present, the extrapolation from animal experiments (mainly rodents), has been employed to evaluate the impacts of PBDEs to human. Therefore, it is important to study different PBDEs congeners in vivo metabolism kinetic parameters. This paper is an overview of absorption, distribution, metabolism and excretion of PBDEs in rodents in vivo. It should be useful for the scientists to carry out the related researches actively for assessing the risks to human health and environmental hazards.