miR-370、Bmi-1、Nrf2在肺癌中的表达及其与临床病理特征的相关性

摘要

目的 分析微小核糖核酸-370(miR-370)、B细胞特异性莫洛氏鼠白血病病毒插入位点1(Bmi-1)、核转录相关因子-2(Nrf2)在肺癌中的表达及其与患者临床病理特征的关系.方法 选择我院收治的73例肺癌患者的癌组织标本,并保留同期38例肺癌患者距肿瘤边缘5 cm的癌旁组织标本.比较miR-370、Bmi-1、Nrf2在肺癌组织及癌旁组织中的表达情况,分析miR-370、Bmi-1、Nrf2表达与肺癌临床病理特征及预后的关系.结果 肺癌组织miR-370高表达率低于癌旁组织, Bmi-1、Nrf2阳性表达率高于癌旁组织,差异均有统计学意义(P0.05),在淋巴结转移、TNM分期中的差异有统计学意义(P0.05). But they showed statistically significant differences between different groups of lymph node metastasis, TNM staging and differentiation degree (P<0.05). The patients with high expression of miR-370 had higher survival rate than those with low expression of miR-370, and patients with Bmi-1 and Nrf2 positive expression had lower survival rate than those with negative expression (P<0.05). COX regression model anal-ysis showed that lymph node metastasis, TNM stage, Bmi-1 and Nrf2 were risk factors for prognosis, while miR-370 was a protective factor. Conclusion The expressions of miR-370, Bmi-1 and Nrf2 are correlated with the clinicopathological characteristics of lung cancer patients. The miR-370, Bmi-1 and Nrf2 could reflect the malignant biological behavior of tumors, so that could be used as a reference index for the prognosis evaluation of lung cancer patients.