Charged particle radiation may exert highly lethal effects even on radioresistant tumors.Although extensive researches are studying the carcinogenesis and carbon ion beam therapy,there is still space to improve the radiosensitivity to cervical cancer in order to reduce radiation dosage.The combination of particle therapy with drug is now rapidly gaining practice in clinics with great expectations for cancer cure[1????3].Thus,strategies to minimize the side effects of radiotherapy while preserving their radiotherapeutic efficacy are needed.Recently,significant attention has been focused on natural radio protective agent in vegetables and fruits.DADS,a major organosulfur compound derived from garlic,induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells as single drugs.Therapeutic approaches based on the combination of high-LET carbon beams and DADS aim at increasing clinical responses while lowering the radiation dosages and cancer cell resistance.The advantage of combination stems from the fact that each one can have a single target or mechanism of action or this combination may share the same target or mechanism of action against cancer cells.Therefore,in this study,we clarify the effect of DADS on the radiation-regulated cell apoptosis,as well as alterations of crucial mediator of the apoptosis pathway in HeLa cells.
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