头孢替唑钠、盐酸头孢甲肟在5转化糖注射液中的配伍稳定性考察

摘要

目的 考察注射用头孢替唑钠、注射用盐酸头孢甲肟分别与5%转化糖注射液配伍的稳定性,为临床合理用药提供依据.方法 在室温(25±1)℃下,将两种注射用抗生素分别与5%转化糖注射液配伍,在8 h内,观察各配伍溶液的pH和外观变化,并采用HPLC法测定各配伍溶液中主药成分的相对含量.结果 8 h内,盐酸头孢甲肟、头孢替唑钠与5%转化糖注射液配伍后,头孢替唑钠的pH、外观和相对含量无明显变化;而盐酸头孢甲肟的pH及含量变化较大,配伍溶液颜色逐渐加深.结论 在室温(25±1)℃条件下、8 h内,注射用头孢替唑钠与5%转化糖注射液的配伍液稳定;从医疗安全的角度考虑不提倡盐酸头孢甲肟与5%转化糖注射液配伍使用.%Aim To study the stability of cefmenoxime hydrochloride for injection and ceftezole sodium for injection respectively in 5％invert sugar injection in order to supply evidence of clinical rational administration. Methods The changes of pH values and external appearances of the two antibiotics were observed after mixed with 5％ invert sugar injection respectively and their relative contents were determined by HPLC within 8 h after mixing at amhient temperature( 25 ± 1 )℃ . Results No significant changes were noted in the relative contents , appearance and pH values of ceftezole sodium with 5％ invert sugar injection within 8 h, however.marted changes were observed in the relative contents and pH values of cefmenoxime hydrochloride and the color of its mixed solution was deepening gradually. Conclusion Ceftezole sodium can be mixed in 5％ invert sugar injection at ambient temperature( 25 ± 1 )℃ within 8 h;but uncler the same condition,cefmenoxime hydrochloride can ' t.