哮喘是儿童常见的慢性气道炎症疾病,以气道变异性炎症和高反应性为特点,对哮喘发病机制的研究,从最初的TH1/TH2范围,已扩展至T调节细胞及促炎症TH17细胞系,转录因子T-bet(TH1)、GATA-3(TH2)、FOXP3(Treg)、RORγτ/RORα(TH17)参与各T细胞亚群分化发展及之间的交叉调节,可能成为哮喘临床治疗潜在的药物靶向点.%Asthma is the frequent chronic disease in childhood and is characterized by chronic airway inflammation and hyperresponsiveness. The investigation of the pathogenesis of this disease has broadened to incorporate the contribution of T regulator cells and proinflammatory TH17 cell lineage, not only TH1 TH2 cell originally. Transcriptional factors such as T -bet, GATA 3, FOXP3, RORγτ/RORα participate in the development of TH1 ,TH2,Treg, and TH17 differentiation and cross regulation among these T cell lineages,and may become the potential pharmacologic targets for clinical treatment of asthma.
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