我院193例药品不良反应报告回顾与分析

摘要

Aim To review and analyze the distribution and characteristic of adverse drug reactions( ADR )so as to provide reference for rnthe rational use of medication in clinics. Methods 193 cases of ADR report had been collected,which were reported in national adverse rndrug reactions monitor network from January to December in 2009 in Kunshan Hospital of Traditional Chinese medicine. All the cases rnwere analyzed from the aspects such as gender,age,method of administration,medicine type and clinical manifestation,etc. Rseults Of rnthe 193 cases of ADR reports, 101 cases were males and 92 cases were females,the proportion between male and female being 1.1:1 ;21 rn～ 40 years old and 41 ～ 60 years old are the two age groups in which the incidence of ADR was the highest; Intravenous administration is rnthe main route of administration which caused ADR. Antimicrobial drug caused the highest proportion of ADR. Among the antimicrobial rndrug, cephalosporin caused the highest proportion. Damage to the skin and its appendages was the main clinical manifestation. Conclusion rnWe should attach greater importance to ADR monitoring,strengthen the clinical management of the rational use of antibiotics and rernduce the incidence of adverse drug reactions.%目的 回顾分析该院药品不良反应(ADR)的发生分布情况和特点,为临床合理用药提供参考.方法 对该院2009年1月至12月收集并上报于全国药品不良反应监测网络的193例ADR报告,分别从性别、年龄、给药途径、涉及的药物种类、临床表现等方面分析、统计.结果 193例ADR报告中,男性101例,女性92例,男女比例为1.1:1,21～40岁、41～60岁两年龄段发生率最高;静脉给药是引发ADR的主要给药途径;抗微生物药引起的ADR比例最高,其中,头孢菌素发生比例最高;临床表现以皮肤及其附件损害为主.结论 应提高对药品不良反应监测工作重要性的认识,加强临床抗菌药物合理使用的管理,减少药品不良反应的发生.