差示分光光度法测定呋塞米片的含量

摘要

Objective To find out a method to determine the Furosemide tablets. Methods The differential absorptions of furosemide in 0. 1 mol · L-1 NaOH and in 0. 1 mol · L-1 HC1 were determined at the detection wavelength of 280 nm. Results The calibration curves showed good linearity in the range from 5. 10 to 40. 84 mg · L-( r = 0. 999 9 ). The average recovery rate ( n =6 )was 99. 69% ,and RSD was 0. 95% . Conclusion The method is simple,quick and accurate,which can be a quality standard of furosemide tablets.%目的 探讨呋塞米片含量测定的方法.方法 在波长280 nm处,呋塞米以其在0.1 mol·L-1氢氧化钠溶液为参比液,测得其在0.1 mol·L-1盐酸溶液中的差示吸收值.结果 呋塞米浓度在5.10～40.84 mg·L-1范围内ΔA与溶液浓度呈良好线性关系(r＝0.999 9),平均回收率为99.69%(n=6),RSD为0.95%.结论 该方法简便、快速、准确,可用于呋塞米片的质量控制.