α-硫辛酸联合甲钴胺治疗2型糖尿病周围神经病变的临床研究

摘要

目的 观察α-硫辛酸(LA)联合甲钴胺对2型糖尿病周围神经病变的治疗效果.方法 选择2008年4月-2012年12月在该科住院的2型糖尿病伴有周围神经病变患者82例,随机分成两组.A组40例给予LA和甲钴胺联合治疗,B组42例给予单用甲钴胺治疗,疗程均为15 d.观察两组治疗前后的临床症状及神经传导速度(NCV).结果 A组治疗总有效率(85.0%)高于B组(69.0%)(P＜0.05);两组治疗后临床症状及神经传导速度均有明显改善(均P＜0.05),但A组的疗效优于B组(P＜0.05);两组均未见明显药物不良反应.结论 α-硫辛酸联合甲钴胺治疗能有效改善2型糖尿病周围神经病变的症状和神经传导速度,可以推广应用临床治疗.%Objective To observe the clinical efficacy of alpha- thioctic acid( LA) combined with mecobalamin in the treatment of type 2 diabetic peripheral neuropathy (DPN). Methods Totally 82 patients with DPN admitted to our hospital from April 2008 to December 2012 were selected and assigned into group A and group B in the application of conventional oral hypoglycemic agents or insulin. 40 patients in group A were given LA (600 mg · d-1) combined with mecobalamin (1. 0 mg · d-1) , while the other 42 patients in group B were given mecobalamin(1.0 mg · d-1) for fifteen days. The symptom and nerve conduction velocity (NCV) were compared before and after treatment of the two groups. Results The results showed that total effectiveness of group A(85.0% )was superior to that of group B(69. 0% ) (P <0. 05) ; Meanwhile, both groups with sensory symptoms and NCV had improved (all P <0. 05 ) , especially obviously in group A (P<0.05) ;The side effects were not found in both groups. Conclusion LA combined mecobalamin treatment of DPN can effectively improve the patients peripheral neuropathy symptoms and NCV,which can be promoted in clinical treatment.