无复流现象和氨基末端脑钠肽前体的关系探讨

摘要

Objective To investigate the correlation of the no-reflow phenomenon with N-terminal pro-brain natriuretic peptide after percutaneous coronary intervention for acute myocardial infarction. Methods The plasma NT-proBNP,hs-CRP and D-D levels in 70 patients with acute myocardial infarction before percutaneous coronary intervention were tested. The patients were divided into no-reflow group and reperfusion group. Results The plasma hs-CRP (25. 44±19. 95) mg·L-1,D-D(537. 47±165. 07) μg·L-1 and NT-proBNP(1350. 71±658. 07) ng·L-1 levels in no-reflow group were significantly higher than the levels of hs-CRP (5. 31±1. 91) mg ·L-1,D-D(363. 91±225. 65) μg·L-1 and NT-proBNP(496. 81±240. 13) ng·L-1 in reperfusion group (P<0. 05). There was significant correlation between NT-proBNP and D-D(r=0. 973,P<0. 05)in no-reflow group,so did NT-proBNP and D-D (r=0. 972, P<0.05).However,there was no significant correlation between NT-proBNP and hs-CRP(r = -0.199,P >0.05)in reperfusion group,so did NT-proBNP and D-D(r= -0. 077,P>0. 05). Conclusions N-terminal pro-brain natriuretic peptide is closely associat-ed with the no-reflow phenomenon after percutaneous coronary intervention for acute myocardial infarction.%目的：探讨急性心肌梗死( AMI)急诊经皮冠状动脉介入治疗( PCI)后无复流现象与氨基末端脑钠肽前体( NT-proBNP)的关系。方法检测70例AMI患者PCI术出现无复流组和再灌注组术前外周静脉血超敏C反应蛋白( hs-CRP)、D-二聚体(D-D)、NT-proBNP的水平。结果比较无复流组和再灌注组的hs-CRP、D-D、NT-proBNP值,无复流组的hs-CRP (25.44±19.95) mg·L-1、D-D(537.47±165.07)μg·L-1、NT-proBNP(1350.71±658.07) ng·L-1,水平PCI术前明显高于再灌注组hs-CRP (5.31±1.91) mg·L-1、D-D(363.91±225.65)μg·L-1、NT-proBNP(496.81±240.13) ng·L-1水平(均P<0.05)。无复流AMI患者NT-proBNP与hs-CRP有明显相关关系(r=0.973,P<0.05),与D-D有明显相关关系(r=0.972,P<0.05)。而再灌注AMI患者NT-proBNP与hs-CRP无明显相关关系(r=-0.199,P>0.05),与D-D无明显相关关系(r=-0.077,P>0.05)。结论急性心肌梗死急诊PCI术无复流现象的发生与NT-proBNP密切相关。