盐酸乙胺丁醇片近红外定量分析模型的建立

摘要

Objective To develop a rapid determination method of the content of ethambutol hydrochloride tablets by a near-infrared re-flectance (NIR)model.Methods We used NIR spectra of ethambutol hydrochloride tablets to establish the NIR content models.Re-sults The root mean square errors of cross validation (RMSECV)was 0.82,and determination coefficient (R2 )was 92.49%.Theroot mean square errors of prediction (RMSEP)was 0.632 and determination coefficient (R2 )was 96.12%.Conclusions Themethod is simple,fast and accurate for the fast determination of the ethambutol hydrochloride tablets.%目的：利用近红外光谱法，建立盐酸乙胺丁醇片含量快速测定方法。方法采集盐酸乙胺丁醇片的近红外（NIR）光谱，建立近红外定量模型。结果盐酸乙胺丁醇片定量模型经内部交叉验证建立预测模型，浓度范围为68．36％～81．52％（mg ·mg-1），决定系数（R2）为92．49％，内部交叉验证预测均方根误差（RMSECV）为0．82。外部验证，决定系数（R2）为96．12％，外部验证预测均方根误差（RMSEP）为0．632。结论该方法快速、简便、无损，结果准确，适用于药品的现场快检。