中国人群中类风湿性关节炎患者外周血T细胞亚群表达的Meta分析

摘要

目的：评价类风湿关节炎（RA ）患者外周血T细胞亚群的变化与RA发病机制及疾病发生、发展的关系。方法检索中国生物医学文献数据库、中国知网和万方数据库，收集和筛选符合条件的研究结果，用Meta分析方法进行相关数据统计。结果纳入12篇研究，Meta分析结果显示RA患者的外周血CD3＋、CD4＋、CD8＋T细胞含量所占的比重较对照组差异无显著性（WMD ＝－0．02，95％CI[－0．07，0．02]，P＝0．27；WMD ＝0．02，95％CI [0．03，0．08]，P＝0．41；WMD ＝－0．03，95％CI[－0．19，0．14]，P＝0．74），但CD4＋／CD8＋比值在类风湿关节炎外周血中较健康组有明显增高（WMD ＝0．81，95％CI[0．74，0．89]，P＜0．001）。结论类风湿关节炎患者外周血中，CD4＋／CD8＋比值失衡可能是RA的发病和发展过程的重要机制。%Objective To evaluate the relationship between variation of T cell subsetsin peripheral blood and the pathogenesis and de-velopment of rheumatoid arthritis (RA).Methods The case-control studies published in China were electronically retrieved in CBM, CNKI and Wanfang Data according to the selection criteria.Meta-analyses were performed for the included studies.Results Twelve pa-pers were subjected to a Meta-analysis.The results showed that there was no statistical difference between peripheral blood of RA and controls:CD3 +[WMD=-0.02,95%CI(-0.07,0.02),P=0.27],CD4 +[WMD=0.02,95%CI(0.03,0.08),P=0.41],CD8 +[WMD=-0.03,95%CI(-0.19,0.14),P=0.74].But CD4 +/CD8 +increased obviously in PB which had difference from con-trols:[WMD=0.81,95%CI (0.74,0.89),P<0.001].Conclusion The imbalance of CD4 +/CD8 +ratio inperipheral blood has great significance for RA’s pathogenesis and development.