Prevalence of Antibiotics in Chinese Outpatient Pediatric Population:A Meta-Analysis

摘要

0bjective: To evaluate the prevalence of antibiotics in the outpatient department of paediatrics in China using data from studies published between 2002 and 2012.Methods: A literature search was performed in three Chinese databases: Wan Fang database,China Journal Full-text database,VIP database to collect data.The random effects model of the meta-analysis was employed according to Meta Analyst Beta 3.13.Subgroups were grouped by geographical region(south and north of China),hospital level(tertiary hospitals and secondary hospitals),study years(2002-2006 and 2007-2012).Results: In total,21 studies were included for this analysis,with a total prescriptions of 127,793 prescriptions and 80,152 antibiotic prescriptions.The pooled prevalence of antibiotics was 65.7％(95％CI: 61.2％～70.0％).It demonstrated that the homogeneity of the references was moderate after heterogeneity test(I2=49.9％).The summarized prevalence of northern and southern China was found to be 59.3％(95％CI: 54.4％～64.0％)and 70.8％(95％CI: 64.8～76.2％)respectively.Prevalence in tertiary hospitals and secondary hospitals were 64.2％(95％CI: 60.3％～67.9％)and 70.3％(95％CI: 53.3％～83.1％)respectively.For the first half and last half of the decade covered in this meta-analysis,pooled prevalence was 64.3％(95％CI: 59.2％～69.2％)and 66.4％(95％CI: 59.2％～72.6％)respectively.Conclusions: The usage rate of antibiotics in outpatient paediatrics was quite high,which should be supervised and managed.