醋酸甲地孕酮在消化道肿瘤患者化疗中的应用观察

摘要

目的：观察醋酸甲地孕酮预防消化道肿瘤患者化疗相关消化道反应的临床意义。方法选取68例消化道肿瘤患者作为研究对象，将其随机数字表法分为对照组和实验组各34例。其中对照组行常规化疗，实验组在进行化疗同时予以醋酸甲地孕酮口服治疗。观察比较两组患者治疗后的食欲、Karnofsky 评分（KPS）、不良反应等。结果实验组患者的食欲增加、KPS 评分改善、体重增加等情况显著优于对照组，差异有统计学意义（P ＜0．05）；对照组患者的骨髓抑制发生率、消化道不良反应发生率均明显高于实验组，差异有统计学意义（P ＜0．05）。结论醋酸甲地孕酮可以预防消化道肿瘤患者化疗的相关毒副反应，提高治疗依从性，改善患者生存质量。%Objective To investigate the clinical significance of megestrol acetate in the treatment of gastrointestinal cancer.Methods A total of 68 gastrointestinal cancer patients were enrolled in this study.Subjects were randomly assigned to the control group(n =34)and the experimental group(n =34).The control group was treated with conventional chemotherapy,while the experimental group was treated with conventional chemotherapy plus adjuvant therapy with megestrol acetate.Appetite,Karnofsky score(KPS)and adverse reactions were observed after treatment.Results Patients in the experimental group had better appetite,increased KPS,and weight gain,which was better than those in the control group with significant difference(P <0.05).The myelosuppression and gastrointestinal tract reaction rates in the control group were higher than those in the experimental group with significant difference(P <0.05).Conclu-sions Megestrol acetate could prevent related adverse reactions during chemotherapy and improve treatment compliance and quality of life.