Objective To analyze the relevance and effect of type 2 diabetes mellitus on liver function in patients with viral hepatitis B cirrhosis. Methods Type 1 diabetes mellitus,hypertension,chronic kidney disease and other congenital organ diseases were excluded according to screening criteria. The data of 150 patients with viral hepatitis B cirrhosis from the Department of infectious diseases of Chaohu Hospital Affiliated to Anhui Medical University were collected,part of which with type 2 diabetes mellitus,to analyze the impact of type 2 diabetes mellitus on liver function in patients with hepatitis B cirrhosis and explore the relation between type 2 diabetes melli-tus and viral hepatitis B cirrhosis. Results With the aggravation viral hepatitis B,type 2 diabetes showed an increasing trend of liver function damage(P < 0. 05),which the difference was statistically significant. There was a negative correlation between serum albumin level and liver function damage in type 2 diabetes mellitus(r = - 0. 393,P < 0. 01). It is positively correlated with alanine aminotrans-ferase(r = 0. 275,P = 0. 01),aspartate aminotransferase(r = 0. 290,P < 0. 01) and the levels of Child-Pugh(r = 0. 290,P < 0. 01).Conclusions Type 2 diabetes can aggravate the degree of liver function damage in patients with viral hepatitis B cirrhosis,which is of great significance for the future guidance of scientific research,and early prevention and treatment of diabetic patients with cirrhosis of the liver.%目的 分析2型糖尿病(T2DM)对乙型病毒性肝炎肝硬化患者肝功能的影响及其相关性.方法 筛选标准应排除1型糖尿病(T1DM),原发性高血压,慢性肾脏病及其他先天性脏器疾病.回顾性分析150例确诊乙型病毒性肝炎肝硬化患者病历资料,其中一部分患者患有T2DM,研究T2DM对乙型病毒性肝炎肝硬化患者肝功能的影响及其相关性.结果 随着乙型病毒性肝炎肝硬化病情的加重(Child-Pugh分级提高),T2DM对肝功能损害呈加重趋势(P<0.05).T2DM对肝功能损害与血清白蛋白呈负相关(r=-0.393,P<0.01),与丙氨酸氨基转移酶(r=0.275,P=0.01),天冬氨酸氨基转移酶(r=0.290,P<0.01)及Child-Pugh分级(r=0.418,P<0.01)呈正相关,均差异有统计学意义(P<0.05).结论 T2DM可加重乙型病毒性肝炎肝硬化患者肝功能受损程度,这对未来指导科学研究,及临床早期防治糖尿病合并肝硬化患者有较大意义.
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