恶性中胚叶混合瘤6例临床病理学特征

摘要

Objective To investigate the clinicopathological features of malignant mullerian mixed tumor (MMMT) in ovary,uterus,cervix.Methods The clinicopathological and imaging features of 6 cases diagnosed MMMT were retrospectively analyzed.Results MMMT epithelial components appeared in the poorly differentiated serous adenocarcinoma,high-differentiation in endometrioid adenocarcinoma,poorly-differentiated squamous cell carcinoma,undifferentiated carcinoma.Mesenchymal components appeared in fibrosarcoma,low grade endometrial stromal sarcoma,leiomyosarcoma,undifferentiated high-level pleomorphic sarcoma and heterology chondrosarcoma.Immunohistochemistry showed that CK expression in epithelium,and Vim,SMA,Desmin,Calponin,S-100,CD10,CD68,CD99 expression in sarcoma.Conclusions MMMT as a highly invasive tumor was diagnosed,according to immunohistochemistry combination with the pathological imaging characteristics.%目的 探讨卵巢、子宫体及子宫颈恶性中胚叶混合瘤(MMMT)的临床病理学特征.方法 收集6例MMMT的临床资料、影像学表现,回顾性分析其临床病理学特征.结果 MMMT的组织学癌为中-低分化浆液性腺癌、高-中分化子宫内膜样腺癌、低分化鳞状细胞癌及未分化癌;肉瘤同源性为纤维肉瘤、低级别子宫内膜间质肉瘤、平滑肌肉瘤及未分化高级别多形性肉瘤,异源性为软骨肉瘤.免疫组化:癌表达细胞角蛋白(CK);肉瘤表达波形蛋白(Vim)、肌动蛋白(SMA)、结蛋白(Desmin)、肌动蛋白结合蛋白(Calponin)、S-100蛋白、CD10、CD68、CD99.结论 MMMT属于高度侵袭性肿瘤,诊断主要依据组织学形态并结合免疫组化染色.