高尿酸血症与代谢综合征关联性的流行病学研究进展

摘要

With the improvement of our country′s economic level and the change of citizens′ lifestyle,the prevalence of metabolic syndrome (MS) is increasing.MS is recognized as an important issue and its prevalence equals to 25.5% in the elders over 60 years old.Metabolic syndrome,a complicated clinical syndrome that involves obesity,hypertension,dyslipidemia,abnormal glucose metabolism and other metabolism disorders,is also an important risk factor for cardiovascular diseases.As the pathogenesis of MS has not yet been fully elucidated,the intervention of its risk factors should be a primary measure for controlling MS.In recent years,lots of researches showed that hyperuricemia (HUA) was a main cause of gout,and it was closely related to major components of MS such as obesity,hypertension,hyperlipidemia,diabetes,etc.It suggested that HUA might be an independent risk factor for MS and cardiovascular diseases.Depending on the study of population epidemiology,this review summerizes the advances in the research of the association between HUA and MS and explores the feasibility of screening high-risk population by serum uric acid,so as to provide scientific basis for the prevention and control of MS and cardiovascular diseases.%随着我国经济水平的提高及居民生活方式的改变,代谢综合征(MS)的患病率不断上升.有研究显示我国老年人群MS患病率高达25.5%,现已成为我国重要的公共卫生问题.MS是集肥胖、高血压、血脂紊乱及糖代谢异常于一体的临床症候群,也是心血管疾病重要的危险因素.由于MS发病机制尚缺乏明确认识,对其危险因素进行干预是目前控制MS的重要手段.近年来,大量研究发现高尿酸血症(HUA)不仅是痛风的主要诱因,且与肥胖、高血压、高脂血症、糖尿病等MS主要组分密切相关,是MS和心血管疾病的独立危险因素.鉴于此,笔者从人群流行病学研究着手,就HUA与MS的关联性作一综述,探索采用血尿酸筛选MS高危人群的可行性,为MS及心血管疾病的防控提供科学依据.