Objective To investigate the clinical effect of interventional therapy combined radiation therapy based on patient -centered treatment for patients with advanced cervical cancer,in order to provide scientific basis to optimize the treatment of cervical cancer. Methods One hundred and seventy-six patients with advanced cervical cancer were selected and assigned into combinational group(n=86)and control group(n=90)according to the method of treatment.Patients in the control group received radical radiotherapy,and patients in the combinational group received interventional therapy combined radiation therapy based on patient -centered.The short-term clinical efficacy,near and long-term adverse reactions,and the recrudescent and survival rates within 1,3 years were recorded and com-pared between the two groups.Results The recently effective rate of combinational group was 91.86%(79/86),and control group was 77.78%(70/90),with statistically significant difference(P<0.05);the main recent adverse effects of both groups were gastroin-testinal reactions,bone marrow suppression,liver and kidney damage,and long-term adverse were radiation dermatitis,radiation procti-tis,radiation cystitis;the occurrence of radiation proctitis,radiation cystitis of combinational group were significantly lower than that of control group(P<0.05);the recrudescent rate of combinational group within 1,3 years were 6.98%(6/86),24.42%(21/86),and control group were 16.67%(15/90),38.89%(35/90),with statistically significant difference(P<0.05);the survival rate of combi-national group within 1,3 years were 93.02%(80/86),75.58%(65/86)and control group were 85.55%(77/90),60.00%(54/90),with statistically significant difference on the survival rate within 3 years(P<0.05),and without statistically significant difference on the survival rate within 1 years(P>0.05).Conclusions Interventional therapy combined radiation therapy based on patient -cen-tered is an effective method for the treatment of advanced cervical cancer,which can significantly improve the therapeutic effect,signifi-cantly improve the survival rate of patients,and is worthy of clinical application.%目的 探讨基于患者为中心的介入治疗与放射治疗联合疗法在中晚期宫颈癌治疗中的临床效果,以期为优化宫颈癌治疗提供科学依据.方法 选取临床Ⅱb期以上的宫颈癌患者176例,根据治疗方法分为联合组(n=86)和对照组(n=90),对照组患者采用单纯根治性放疗,联合组患者则接受基于患者为中心的介入治疗与放射治疗联合疗法,比较两组患者近期临床疗效和近期、远期不良反应,统计并比较两组患者1、3年复发转移率和生存率.结果 联合组近期有效率为91.86%(79/86),对照组为77.78%(70/90),组间比较差异有统计学意义(P<0.05);两组患者近期不良反应均表现为消化道反应、骨髓抑制、肝肾损害,远期不良反应表现为放射性皮炎、放射性直肠炎、放射性膀胱炎,联合组患者放射性直肠炎、放射性膀胱炎的发生率均明显低于对照组患者(P<0.05);联合组患者1、3年内复发转移率分别为6.98%(6/86)、24.42%(21/86),对照组患者分别为16.67%(15/90)、38.89%(35/90),组间均差异有统计学意义(P<0.05);联合组患者1、3年内生存率分别为93.02%(80/86)、75.58%(65/86),对照组患者分别为85.55%(77/90)、60.00%(54/90),组间3年内生存率均差异有统计学意义(P<0.05),但1年内生存率差异无统计学意义(P>0.05).结论 基于患者为中心的介入治疗与放射治疗联合疗法是治疗中晚期宫颈癌的有效方法,可显著提高治疗效果,明显提高患者生存率,值得临床推广应用.
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