超声结合血清维生素D结合蛋白检测在急性胰腺炎诊断中的价值

摘要

目的 探讨多普勒超声与维生素D结合蛋白(VDBP)水平相结合用于提高急性胰腺炎的诊断效率.方法 回顾性分析95例急性胰腺炎的彩色多普勒诊断结果和患者入院第1天VDBP水平,并与50名健康成人VDBP水平对比分析.结果 超声诊断急性胰腺炎的灵敏度为76.84％,特异度为78.00％;入院后第1天患者血清VDBP水平与正常对照组VDBP含量比较发现,急性胰腺炎患者入院第1天的血清VDBP低于正常对照组,差异有统计学意义.超声结合VDBP蛋白水平降低诊断急性胰腺炎与金标准对比分析,灵敏度为94.74％,特异度为80.00％;单纯超声诊断对应的ROC曲线下面积为0.759,超声与VDBP联合诊断为0.878(P<0.01).结论 彩色多普勒对诊断急性胰腺炎具有较高的诊断效力,但仍存在不足,通过结合患者血清VDBP水平能够提高急性胰腺炎的诊断率.%Objective To explore the diagnosis efficiency of acute pancreatitis by the combination of Doppler ultrasound and vitamin D Binding protein( VDBP) level. Methods A retrospective analysis was made of 95 cases of acute pancreatitis in the color Doppler diag-nosis results and VDBP levels of patients on the first day of hospital admission,which was compared with VDBP levels of 50 cases of healthy adults. Results The sensitivity of ultrasonography in the diagnosis of acute pancreatitis was 76. 84％ and the specificity was 78. 00％. The serum vitamin D binding protein levels of the patients on the first day of hospital admission were,compared with that of the normal control group,lower than the normal control group with statistically significant difference. The sensitivity of ultrasound com-bined with decreased VDBP protein level in the diagnosis of acute pancreatitis,when compared with the gold standard,was 94. 74％, and the specificity was 80. 00％. The area under receiver operator characteristic ( ROC) curve of the ultrasonic diagnosis was 0. 759, while that of ultrasound and VDBP combined method was 0. 878(P<0. 01). Conclusions Color Doppler has a high diagnostic effi-ciency for the diagnosis of acute pancreatitis,but there are still some weaknesses,which can be improved through the combined analysis of the patient′s serum VDBP level.