抗环瓜氨酸肽抗体与系统性红斑狼疮伴发关节炎的相关性研究

摘要

Objective To invesigate the clinical significance of anti - cyclic citrullinated peptides antibodies ( anti - CCP) in systemic lupus erythematosus (SLE) patients with arthritis, and to explore the association of anti - CCP with erosive arthritis and judge prognosis in SLE patients. Methods 145 SLE patients were examined for anti - CCP and IgM - RF with enzyme - linked immunosorbent assay method and rate turbidimetric method. Results The frequency of ant - CCP was 24. 1 % in this group of SLE patients. The frequency of arthritis was significantly higher in SLE patients with anti - CCP than without anti - CCP (77. 1% VS 38. 2% ,P <0.05). Anti - CCP antibodies were more frequently detected in SLE patients with arthritis than those without arthritis (39.1% VS10.5%,P<0.05). The frequency of RF - positive group with Anti - CCP than that without anti - CCP was (38. 5% VS 24.4% , P < 0. 05). When compared with anti - CCP negative patient, erosive arthritis occurred more often in anti - CCP positive patients than nagative anti - CCP patients ( 25.1% VS 4.6% ,P <0.001). Conclusion Anti - CCP antibodies have a prevalence in our group of SLE patients and its presence is closely associated with e-rosion of bone and joint destruction.%目的研究抗环瓜氨酸肽(CCP)抗体在系统性红斑狼疮(SLE)患者中的临床意义,探讨抗CCP抗体与SLE患者伴发关节炎、骨侵蚀破坏的关系及判断预后的意义.方法采用酶联免疫吸附试验( ELISA)法和速率比浊法检测145例SLE患者血清中抗CCP抗体和IgM - RF.结果抗CCP抗体在SLE患者中的阳性率为24.1％.抗CCP抗体阳性的SLE患者关节炎的发生率明显高于抗CCP抗体阴性者(77.1％与38.2％,P＜0.05).SLE伴发关节炎组抗CCP抗体阳性率(39.1％)高于非关节炎组(10.5％)(P＜0.05)；抗CCP抗体阳性组RF阳性率(38.5％)高于抗CCP抗体阴性组(24.4％)(P＜0.05).抗CCP抗体阳性患者较阴性患者侵蚀性关节炎的比例显著升高(25.7％与4.6％,P＜0.01).结论24.1％的SLE患者出现抗CCP抗体,抗CCP抗体的出现与SLE伴发关节炎和骨关节侵蚀性破坏密切相关.