目的 探讨支气管哮喘合并反复呼吸道感染患儿补锌治疗的I临床效果.方法 选取2岁1个月一12岁支气管哮喘合并反复呼吸道感染的患儿86例,按双盲法随机分为治疗组与非治疗组,两组患儿均继续吸入原剂量的糖皮质激素(布地奈德气雾剂),在感染的发作期给予抗生素或抗病毒及解痉平喘等治疗,治疗组另外加以补锌,观察患儿治疗后呼吸道感染、哮喘发作持续时间、抗生素使用时间以及治疗前后2个月血清IgA、IgG、IgM水平.结果 治疗组患儿临床症状、治疗效果明显好于对照组,治疗以后2个月血清IgA、IgG水平较治疗前以及对照组升高,而IgM水平无明显改变.结论 对支气管哮喘合并反复呼吸道感染经正规吸入糖皮质激素控制不理想的患儿给予补锌治疗,可以有效预防反复呼吸道感染,从而减少哮喘发作次数,减轻哮喘严重程度,且安全可靠,使用方便.%Objective To explore the clinical effect of Added Zinc in treating asthma with recurrent respiratory infections (RRI) in rnchildren. Methods 86 children with asthma and RRI were randomly divided into two double - blinded group of the add zinc group and the rncontrol group. All the children Inhaled the original dose of corticosteroids, And when the infection was out broken, they were given either anrntibiotics or antiviral and antispasmodics. The incidence of RRI, days of asthma attack, days of antibiotic usage and levels of serum IgA, IgG rnand IgM 2 months before and after the treatment were observed. Results After treated with Zinc, it was showed that there were remarkable rnclinical responses with reductions in the number of infective episodes, days of asthma attack, days of antibiotic usage. These differences were rnall statistically significant (P ＜ 0.01 ). 2 months after the treatment, the levels of serum IgA, IgG increased significantly in added zinc group rn( P ＜ 0. 01 ), but there were no significant changes in the level of serum IgM ( P > 0. 05 ). Conclusion The present data shows that added rnzinc has significant clinical efficacy and excellent tolerability in treating children having asthma with RRI.
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