单纯性肥胖症儿童促酰化蛋白和脂联素水平变化的临床意义

摘要

Objective To explore the relationship between acylation stimulating protein(ASP),adiponectin(ADPN)and the inci-dence of childhood obesity and the significance of them in diagnoses and therapy of children's obesity. Methods 200 children including 62 obese children,73 overweight children and 65 healthy control children were recruited. Fasting plasma glucose (FPG),fasting insulin (FINS),total cholesterol(TC),triglyeerides (TG),low density lipoprotein-cholesterol (LDL-C),and HDL-C (high density lipoprotein-cholesterol)were determined by automatic blood analyses machine. Serum ASP and ADPN levels were determined by enzyme linked immu-nosorbent assay(ELISA). Results Compared with healthy children group,FPG,FINS,LDL-C,TC,TG,insulin resistance index(IRI), ASP of obese and overweight children groups were significantly higher(P < 0. 05),while the level of HDL-C,ADPN and insulin sensitivity index(ISI)were significantly lower(P < 0. 05). And there was significant difference in the levels of FPG,FINS,LDL-C,TC,TG and IRI between obese and overweight children groups(P < 0. 05). ASP was negatively connected with ADPN in neonates with HIE. Conclusion In simple obesity children,there was a significant change in serum ASP and ADPN. And ASP and ADPN were involved in the disorder of lipid metabolism in obese children. Serum ASP and ADPN levels can be used as a new indicator to evaluate the risk of childhood obesity trends and future evaluation of diabetes and cardiovascular diseases.%目的：探讨单纯性肥胖症儿童促酰化蛋白（ASP）和脂联素（ADPN）水平变化的临床意义。方法选取2014年1月至2014年12月惠州市第一妇幼保健院儿科内分泌门诊就诊及健康体检的200例儿童作为研究对象，其中单纯性肥胖组62例，超重组73例和健康对照组65例。根据患者的身高和体质量计算出体质量指数（BMI）。测定空腹血糖（FPG）、空腹胰岛素（FINS）、总胆固醇（ TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）、促酰化蛋白（ASP）和脂联素（ADPN）。结果与健康对照组比较，肥胖组和超重组的 FPG、FINS、LDL-C、TC、TG、ASP和胰岛素抵抗指数（IRI）均升高（P ＜0.05）；HDL-C、ADPN和胰岛素敏感指数（ISI）均降低（P ＜0.05）。与超重组比较，肥胖组的 FPG、FINS、LDL-C、TC、TG、ASP和 IRI均升高，差异有统计学意义（P ＜0.05）；HDL-C、ADPN和 ISI显著降低（P ＜0.05）。血清 ASP和 ADPN的浓度变化呈负相关。结论单纯性肥胖症儿童体内脂肪细胞因子ASP水平显著升高，而ADPN显著降低，并与BMI、血脂代谢及胰岛抵抗密切相关。