冠状动脉侧支循环与其相关生物标志物的研究进展

摘要

冠状动脉侧支循环的形成对于急性心肌梗死患者的预后极其重要,目前对冠状动脉侧支循环的评估仅限于一些侵入性操作,如冠状动脉造影和Rentrop分级,具有创伤大、操作复杂、花费高等缺点.近年来,相关文献表明,侧支循环的形成可以通过一些生物标志物来评估,例如血浆同型半胱氨酸水平、脂蛋白a以及生长分化因子-15等,但其特异性仍需进一步研究.现就近年来相关生物标志物对冠状动脉侧支循环形成的相关进展做一综述.%The formation of coronary collateral circulation is very important for the prognosis of patients with acute myocardial infarction. The assessment of the collateral circulation of the coronary arteries is limited to some invasive operations, such as coronary angiography and Rentrop classification, which have the disadvantages of large trauma, complicated operation and high cost. In recent years, the relevant literature has shown that the formation of collateral circulation can be evaluated by some biomarkers, such as plasma homocysteine, lipoprotein (a), and growth differentiation factor-15, but the specificity still needs further study. This article gives a brief overview of the progress of the formation of coronary collateral circulation by related biomarkers in recent years.