组织工程心脏瓣膜的研究进展

摘要

Valve replacement is currently still the most effective treatment option for valvular heart disease. However, clinical efficacy of artificial heart valves is far from satisfactory. The discovery and development of tissue engineering opens the door to many new alternatives. This article reviews advancements in tissue engineering heart valves including the selection of seed cells, the choice of scaffold material, the methods of valve formation in vitro, the efficacy of using animals, and clinical application.%心脏瓣膜置换术仍然是当前治疗心脏瓣膜病最有效的治疗方法,但目前临床应用的人工心脏瓣膜疗效却不尽如人意.随着组织工程学的兴起与发展,组织工程心脏瓣膜的研究越来越受到关注并成为研究的热点.现对组织工程心脏瓣膜研究在种子细胞的选择、支架材料的选择、瓣膜体外构建方法、动物实验与临床应用等方面取得的进展,进行综述.