EGFR、pEGFR蛋白在非小细胞肺癌中的表达及临床意义

摘要

Objective To explore the potential roles and their clinical significance of EGFR and pEGFR protein expressions in NSCLC tumor tissues. Methods EGFR and pEGFR protein expressions were detected in 140 cases of NSCLC tissues and corresponding adjacent normal lung tissues by using immunohistochemistry SP method. Results The expressions of EGFR and pEGFR protein in NSCLC tissues were significantly higher than those in normal control. There was no relationship between EGFR protein expression and pathological features of NSCLC. But pEGFR protein expression was correlated with gender,smoking status and histological type. Conclusion The high expression of EGFR and pEGFR protein in lung cancer cells may play a key role in NSCLC.%目的 探讨表皮生长因子受体(EGFR)和磷酸化表皮生长因子受体(pEGFR)蛋白在非小细胞肺癌(NSCLC)组织和癌旁正常肺组织中的表达情况,探讨其临床意义.方法 采用免疫组化法检测140例NSCLC组织及癌旁正常肺组织中EGFR和pEGFR蛋白的表达.结果 EGFR和pEGFR蛋白在肺癌组织中的表达高于癌旁正常肺组织,差异有统计学意义(P＜0.05).EGFR的表达与临床病理学类型均无关;pEGFR的表达与患者性别、吸烟与否及组织学类型有关.结论 EGFR和pEGFR蛋白过表达可能与NSCLC的发生发展有相关性.