146 patients with severe plaque psoriasis were randomly divided into Group A, B and C. In Group A ( Treatment Group ), 49 patients were given NB-UVB irradiation three times a week and applied tazarotene 0. 05% gel once a night. In Group B( Control Group 1 ), 48 cases were only given NB-UVB irradiation three times a week. The other patients in Group C ( Control Group 2 ) were only applied tazarotene 0. 05% gel every night. All the patients were given a small dose[ 0. 3 ~ 0. 5 mg/( kg·d ) ]of acitretin. The clinical efficacy was evaluated 4 weeks and 8 weeks after treatment respectively. The follow-up recurrence was assessed 12 weeks after treatment. After 8 weeks treatment, the effective rates of group A, B and C were 93.9% , 72.9% and 69.4% respectively. The difference between Group A, Group B and Group A, Group C were both statistically significant ( P < 0. 05 ) and relative severe side-effects had not occurred. The recurrence rate in Group A was obviously lower than that of Group B and C.%入选的重度斑块型银屑病患者146例,采用随机方式,将病例分为治疗组(A组,n=49),给予窄谱中波紫外线(NB-UVB)照射,每周3次,并每晚外用0.05%他扎罗汀凝胶1次;单纯NB-UVB治疗组(B组,n=48),单纯给予NB-UVB照射;单纯他扎罗汀治疗组(C组,n=49),单纯给予0.05%他扎罗汀凝胶外用.3组患者均给予小剂量阿维A口服,4、8周后分别评价疗效,疗程结束12周随访复发情况.结果 显示,A、B、C 3组有效率分别为93.9%、72.9%、69.4%,3组间比较差异有统计学意义(P<0.05),未出现较严重的毒副作用,A组复发率也明显低于B组和C组.
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